Current state and challenges in respiratory syncytial virus drug discovery and development

G Zou, S Cao, Z Gao, J Yie, JZ Wu - Antiviral Research, 2023 - Elsevier
Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract
infections (LRTI) in young children and elderly people worldwide. Recent significant …

[HTML][HTML] Prediction and evolution of the molecular fitness of SARS-CoV-2 variants: introducing SpikePro

F Pucci, M Rooman - Viruses, 2021 - mdpi.com
The understanding of the molecular mechanisms driving the fitness of the SARS-CoV-2 virus
and its mutational evolution is still a critical issue. We built a simplified computational model …

[HTML][HTML] SARS-CoV-2: outline, prevention, and decontamination

E Janik, M Bartos, M Niemcewicz, L Gorniak, M Bijak - Pathogens, 2021 - mdpi.com
The new coronavirus began to spread around the world in late 2019. Initially, it was found
only in China, but in the following days there were reported cases of infections in other …

[HTML][HTML] Upregulation of the renin–angiotensin system pathways and SARS-CoV-2 infection: the rationale for the administration of zinc-chelating agents in COVID-19 …

L Zamai - Cells, 2021 - mdpi.com
The article describes the rationale for the administration of zinc-chelating agents in COVID-
19 patients. In a previous work I have highlighted that the binding of the SARS-CoV spike …

[HTML][HTML] Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies

M Liu, H Gan, Z Liang, L Liu, Q Liu, Y Mai… - Frontiers in …, 2023 - frontiersin.org
COVID-19 pandemic is a global public health emergency. Despite extensive research, there
are still few effective treatment options available today. Neutralizing-antibody-based …

[HTML][HTML] Epitope mapping of severe acute respiratory syndrome coronavirus 2 neutralizing receptor binding domain-specific monoclonal antibodies

F Maghsood, MM Amiri, AH Zarnani, V Salimi… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the outbreak led to the coronavirus disease 2019 (COVID-19) pandemic. Receptor binding …

Immunoregulatory nanomedicine for respiratory infections

Y Xiao, Y Huang, M Xie, M Yang, Y Tao, L Liu… - Nature Reviews …, 2024 - nature.com
Immune-regulation strategies, such as vaccination and immunotherapy, are key to the
prevention and treatment of respiratory infectious diseases. In particular, nanomedicines can …

[HTML][HTML] Molecular perspectives of SARS-CoV-2: pathology, immune evasion, and therapeutic interventions

M Shah, HG Woo - Molecules and Cells, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) has not only affected human health
but also diverted the focus of research and derailed the world economy over the past year …

[HTML][HTML] Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

R Yin, JD Guest, G Taherzadeh… - PLoS Computational …, 2021 - journals.plos.org
The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of
protective antibody responses. This is underscored by the emergence and spread of SARS …

[HTML][HTML] Multidimensional futuristic approaches to address the pandemics beyond COVID-19

SB Kotwal, N Orekondey, GP Saradadevi… - Heliyon, 2023 - cell.com
Globally, the impact of the coronavirus disease 2019 (COVID-19) pandemic has been
enormous and unrelenting with∼ 6.9 million deaths and∼ 765 million infections. This …