First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine

L Martínez, I Malaina, D Salcines-Cuevas… - Scientific Reports, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the
present time, and considerable public and private effort is being devoted to fighting this …

Role of laboratory medicine in SARS-CoV-2 diagnostics. Lessons learned from a pandemic

I Duś-Ilnicka, A Szymczak, M Małodobra-Mazur… - Healthcare, 2021 - mdpi.com
Since the 2019 novel coronavirus outbreak began in Wuhan, China, diagnostic methods in
the field of molecular biology have been developing faster than ever under the vigilant eye …

Structure-based epitope design: Toward a greater antibody–SARS-CoV-2 RBD affinity

H Traboulsi, MA Khedr, YSS Al-Faiyz, R Elgorashe… - ACS …, 2021 - ACS Publications
Efficient COVID-19 vaccines are widely acknowledged as the best way to end the global
pandemic. SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to …

Full-length computational model of the SARS-CoV-2 spike protein and its implications for a viral membrane fusion mechanism

W Nishima, M Kulik - Viruses, 2021 - mdpi.com
The SARS-CoV-2 virus has now become one of the greatest causes of infectious death and
morbidity since the 1918 flu pandemic. Substantial and unprecedented progress has been …

Human Superantibodies to 3CLpro Inhibit Replication of SARS-CoV-2 across Variants

K Glab-Ampai, K Kaewchim, T Saenlom… - International Journal of …, 2022 - mdpi.com
Broadly effective and safe anti-coronavirus agent is existentially needed. Major protease
(3CLpro) is a highly conserved enzyme of betacoronaviruses. The enzyme plays pivotal role …

Induction of broadly cross-reactive antibody responses to SARS-CoV-2 variants by S1 nanoparticle vaccines

C Sun, RY Yuan, C Xie, JF Sun, XY Fang… - Journal of …, 2022 - Am Soc Microbiol
Despite the rapid deployment of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) vaccines, the emergence of SARS-CoV-2 variants and reports of their immune …

Antiviral treatment selection for SARS-CoV-2 pneumonia

M Bassetti, S Corcione, S Dettori… - Expert Review of …, 2021 - Taylor & Francis
Introduction Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms
that include drugs aimed at reducing disease progression by counteracting two different, but …

Latest updates on SARS-CoV-2 genomic characterization, drug, and vaccine development; a comprehensive bioinformatics review

MM Sakr, NS Elsayed, GS El-Housseiny - Microbial pathogenesis, 2021 - Elsevier
Amid the COVID-19 outbreak, several bioinformatic analyses have been conducted on
SARS-CoV-2 virus genome. Numerous studies rushed to fill the gap about this novel virus …

A comprehensive investigation regarding the differentiation of the procurable COVID-19 vaccines

S Banerjee, D Banerjee, A Singh, VA Saharan - AAPS PharmSciTech, 2022 - Springer
COVID-19 caused by coronavirus SARS-CoV-2 became a serious threat to humankind for
the past couple of years. The development of vaccine and its immediate application might be …

Effect of Ivermectin prophylaxis in prevention of COVID 19: Meta-analysis and systematic review

M Kujur, KA Kiran, AR Nag, A Kujur… - Journal of family …, 2022 - journals.lww.com
Ivermectin was popular drug on trial for preventive and therapeutic role in COVID-19.
However, there is disagreement concerning the validity of its clinical efficacy. Hence, we …