Endogenously produced SARS-CoV-2 specific IgG antibodies may have a limited impact on clearing nasal shedding of virus during primary infection in humans

S Yang, KR Jerome, AL Greninger, JT Schiffer, A Goyal - Viruses, 2021 - mdpi.com
While SARS-CoV-2 specific neutralizing antibodies have been developed for therapeutic
purposes, the specific viral triggers that drive the generation of SARS-CoV-2 specific IgG …

[HTML][HTML] Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: allosteric communications between and within viral …

V Barozi, AL Edkins, ÖT Bishop - Computational and Structural …, 2022 - Elsevier
The interaction between the Spike (S) protein of SARS-CoV-2 and the human angiotensin
converting enzyme 2 (hACE2) is essential for infection, and is a target for neutralizing …

[HTML][HTML] New perspective towards therapeutic regimen against SARS-CoV-2 infection

V Srivastava, A Ahmad - Journal of Infection and Public Health, 2021 - Elsevier
The ongoing enormous loss of human life owing to Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2), has led to a global crisis ranging from the collapse of health …

Unbinding of hACE2 and inhibitors from the receptor binding domain of SARS-CoV-2 spike protein

L Mishra, T Bandyopadhyay - Journal of Biomolecular Structure …, 2023 - Taylor & Francis
The first direful biomolecular event leading to COVID-19 disease is the SARS-CoV-2 virus
surface spike (S) protein-mediated interaction with the human transmembrane protein …

Structure-Based Epitope Design: Toward a Greater Antibody–SARS-CoV-2 RBD Affinity

H Traboulsi, MA Khedr, YSS Al-Faiyz, R Elgorashe… - ACS …, 2021 - ACS Publications
Efficient COVID-19 vaccines are widely acknowledged as the best way to end the global
pandemic. SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to …

[PDF][PDF] Twindemic of coronavirus disease (COVID-19) and cardiometabolic diseases

GHR Rao - International Journal of Biomedicine, 2021 - researchgate.net
Metabolic diseases, like hypertension, excess weight, obesity, type 2 diabetes, and vascular
diseases, have rapidly increased to epidemic proportions worldwide. Metabolic risks (such …

[PDF][PDF] Role of laboratory medicine in SARS-CoV-2 diagnostics

I Dus-Ilnicka, A Szymczak… - … learned from a …, 2021 - pdfs.semanticscholar.org
Since the 2019 novel coronavirus outbreak began in Wuhan, China, diagnostic methods in
the field of molecular biology have been developing faster than ever under the vigilant eye …

Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern

AJ Griffin, KL O'Donnell, K Shifflett, JP Lavik… - Scientific reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in a variety of
clinical symptoms ranging from no or mild to severe disease. Currently, there are multiple …

Structural and energetic profiling of SARS-CoV-2 antibody recognition and the impact of circulating variants

R Yin, JD Guest, G Taherzadeh, R Gowthaman, I Mittra… - bioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of
protective antibody responses. This is underscored by the emergence and spread of SARS …

COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants

D Junker, A Dulovic, M Becker, TR Wagner, PD Kaiser… - medRxiv, 2021 - medrxiv.org
As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest
in the longevity of immune protection, especially with regard to increasingly infectious virus …