HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …

HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …

Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

More than 40 years into the pandemic, HIV remains a global burden and as of now, there is
no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been …

Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …

There is an urgent unmet medical need for novel human immunodeficiency virus type 1 (HIV-
1) inhibitors that are effective against a variety of NNRTI-resistance mutations. We report our …

HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active
antiretroviral therapy (HAART), which has achieved great success in controlling AIDS …

Although non-nucleoside reverse transcriptase inhibitors (NNRTIs) exhibit potent anti-HIV-1
activity and play an important role in the active antiretroviral therapy of AIDS, the emergence …

The biorelevant sulfur-containing Euphorbia diterpenes with scarce 5/7/6/3 premyrsinane-
and 5/7/6 myrsinane-type backbones were easily constructed from naturally abundant …