[HTML][HTML] Phosphodiesterase-5 inhibitors tadalafil and sildenafil potentiate nitrergic-nerve mediated relaxations in the bladder vasculature

D Nilsson, R Chess-Williams, D Sellers - European Journal of …, 2023 - Elsevier
Recent studies suggest that lower urinary tract dysfunction may arise due to changes in local
perfusion. Phosphodiesterase-5 inhibitors can improve urinary bladder blood flow, although …

Towards in silico Models of the Inflammatory Response in Bone Fracture Healing

L Lafuente-Gracia, E Borgiani, G Nasello… - … in Bioengineering and …, 2021 - frontiersin.org
In silico modeling is a powerful strategy to investigate the biological events occurring at
tissue, cellular and subcellular level during bone fracture healing. However, most current …

Validation of airway porcine epithelial cells as an alternative to human in vitro preclinical studies

VG Genna, D Adamo, G Galaverni, F Lepore… - Scientific Reports, 2023 - nature.com
Animal models are currently used in several fields of biomedical research as useful
alternatives to human-based studies. However, the obtained results do not always effectively …

Recognising the potential of large animals for modelling neuromuscular junction physiology and disease

SD Cahalan, I Boehm, RA Jones… - Journal of Anatomy, 2022 - Wiley Online Library
The aetiology and pathophysiology of many diseases of the motor unit remain poorly
understood and the role of the neuromuscular junction (NMJ) in this group of disorders is …

Industrial development of standardized fetal progenitor cell therapy for tendon regenerative medicine: Preliminary safety in xenogeneic transplantation

A Laurent, P Abdel-Sayed, A Grognuz, C Scaletta… - Biomedicines, 2021 - mdpi.com
Tendon defects require multimodal therapeutic management over extensive periods and
incur high collateral burden with frequent functional losses. Specific cell therapies have …

An update on applications of cattle mesenchymal stromal cells

B Merlo, PM Gugole, E Iacono - Animals, 2022 - mdpi.com
Simple Summary Among livestock species, cattle are crucially important for the meat and
milk production industry. Cows can be affected by different pathologies, such as mastitis …

Surgical classification for preclinical rat femoral bone defect model: standardization based on systematic review, anatomical analysis and virtual surgery

Y Sun, H Helmholz, R Willumeit-Römer - Bioengineering, 2022 - mdpi.com
Though surgical techniques profoundly influence in vivo experiments, significant
heterogeneity exists in current surgeries for inducing rat femoral bone defects. Such …

Sodium selenite preserves rBM-MSCs' stemness, differentiation potential, and immunophenotype and protects them against oxidative stress via activation of the Nrf2 …

B Rahimi, M Panahi, H Lotfi, M Khalili, A Salehi… - … Medicine and Therapies, 2023 - Springer
Background The physiological level of reactive oxygen species (ROS) is necessary for many
cellular functions. However, during the in-vitro manipulations, cells face a high level of ROS …

Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes

F Canonici, D Marcoccia, P Bonini, V Monteleone… - Biomedicines, 2023 - mdpi.com
Subchondral bone cysts in horses represent one of the main causes of lameness that can
occur in different anatomical locations. The study describes the treatment in regenerative …

Cryopreservation methods and frontiers in the art of freezing life in animal models

FS Aljaser - Anim. Reprod, 2022 - books.google.com
The development in cryobiology in animal breeding had revolutionized the field of
reproductive medicine. The main objective to preserve animal germplasm stems from variety …