The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the
constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so …

A rare disease is defined by its low prevalence in the general population. Although the fixed
threshold slightly varies between different countries, a specific disorder is usually …

Objectives To explore the possibility of kidney organoids generated using patient derived
human induced pluripotent stem cells (hiPSC) for modeling of Fabry disease nephropathy …

The aim of this study is to explore the possibility of modeling Gitelman's disease (GIT) with
human-induced pluripotent stem cell (hiPSC)-derived kidney organoids and to test whether …

Background: Renal tubular acidosis (RTA) is caused by various disruptions to the secretion
of H+ by distal renal tubules and/or dysfunctional reabsorption of HCO 3− by proximal renal …

Renal tubules play an important role in maintaining water, electrolyte, and acid–base
balance. Renal tubule dysfunction can cause electrolyte disorders and acid–base …

Metabolic acid-base disturbances are frequently encountered in the emergency department,
and many of these patients are critically ill. In the evaluation of patients with these maladies …

Gitelman syndrome (GS) is a rare, autosomal recessive, salt‐losing tubulopathy caused by
loss of function in the SLC12A3 gene (NM_000339. 2), which encodes the natrium chloride …

In this study, we used in silico techniques to identify available parasite treatments,
representing a promising therapeutic avenue. Building upon our computational initiatives …

Genetic kidney diseases (GKDs) are a group of rare diseases, affecting approximately about
60 to 80 per 100,000 individuals, for which there is currently no treatment that can cure them …