Objectives: To determine whether a multidisciplinary, multimodal Patient Blood Management
(PBM) program for patients undergoing surgery is effective in reducing perioperative …

Background Antifibrinolytics reduce death from bleeding in trauma and post-partum
haemorrhage. We examined the effect of treatment delay on the effectiveness of …

Cardiac surgery is associated with perioperative blood loss and a high risk of allogeneic
blood transfusion. Patient blood management (PBM) in cardiac surgery contributes to the …

Bleeding after cardiac surgery is a common and serious complication leading to transfusion
of multiple blood products and resulting in increased morbidity and mortality. Despite the …

Normal haemostasis depends on an intricate balance between mechanisms of bleeding and
mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI) …

Background The use of tranexamic acid reduces mortality due to postpartum hemorrhage.
We investigated whether the prophylactic administration of tranexamic acid in addition to …

Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric
complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes …

Importance Tranexamic acid is recommended for reducing blood loss and transfusion in
cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid …

Cardiopulmonary bypass (CPB) has allowed for significant surgical advancements, but
accompanying risks can be significant and must be expertly managed. One of the foremost …

Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or
prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding …