Autism spectrum disorders (ASD) are characterized by two seemingly unrelated symptom
domains—deficits in social interactions and restrictive, repetitive patterns of behavioral …

Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

Fragile X syndrome (FXS) patients do not make the fragile X mental retardation protein
(FMRP). The absence of FMRP causes dysregulated translation, abnormal synaptic …

Many available drugs have been repurposed as treatments for neurodevelopmental
disorders. In the specific case of fragile X syndrome, many clinical trials of available drugs …

The most common inherited monogenetic cause of intellectual disability is Fragile X
syndrome (FXS). The clinical symptoms of FXS evolve with age during adulthood; however …

Abstract Chromosome 15q11. 2–q13. 1 duplication syndrome (Dup15q syndrome) is a
severe neurodevelopmental disorder characterized by intellectual disability, impaired motor …

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the
FMR1 gene. It is a leading monogenic cause of autism spectrum disorder and inherited …

Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have
sensory processing deficits, such as hypersensitivity to auditory, tactile, and visual stimuli …

Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic
plasticity that are believed to underlie declarative memory. We previously showed that …

Angelman syndrome (AS), a neurodevelopmental disorder associated with intellectual
disability, is caused by loss of maternal allele expression of UBE3A in neurons. Mouse …