[HTML][HTML] Cellular senescence and senolytics: the path to the clinic

S Chaib, T Tchkonia, JL Kirkland - Nature medicine, 2022 - nature.com
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

[HTML][HTML] COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

[HTML][HTML] Mucosal immune responses to infection and vaccination in the respiratory tract

RC Mettelman, EK Allen, PG Thomas - Immunity, 2022 - cell.com
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

[HTML][HTML] SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …

[HTML][HTML] Immune senescence, immunosenescence and aging

KA Lee, RR Flores, IH Jang, A Saathoff… - Frontiers in …, 2022 - frontiersin.org
With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …

Cellular senescence and the tumour microenvironment

M Takasugi, Y Yoshida, N Ohtani - Molecular oncology, 2022 - Wiley Online Library
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …

[HTML][HTML] Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19

C Matsumoto, S Shibata, T Kishi, S Morimoto… - Hypertension …, 2023 - nature.com
Abstracts The coronavirus disease 2019 (COVID-19) affects infected patients even after the
acute phase and impairs their health and quality of life by causing a wide variety of …

COVID-19 and Long COVID: disruption of the neurovascular unit, blood-brain barrier, and tight junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

[HTML][HTML] Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype

T Matsudaira, S Nakano, Y Konishi… - Communications …, 2023 - nature.com
Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular
stresses, is critically involved in age-related tissue dysfunction in various organs. However …

[HTML][HTML] Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …