[HTML][HTML] Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin

X Tian, Y Li, Y Shen, Q Li, Q Wang… - Oncology …, 2015 - spandidos-publications.com
Abstract Cordycepin, a 3-deoxyadenosine, is the predominant functional component of the
fungus Cordyceps militaris, a traditional Chinese medicine. Previous studies investigating …

Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent

M Serpi, V Ferrari, C McGuigan… - Journal of Medicinal …, 2022 - ACS Publications
3′-Deoxyadenosine (3′-dA, Cordycepin, 1) is a nucleoside analogue with anticancer
properties, but its clinical development has been hampered due to its deactivation by …

Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway

C Cheng, X Zhu - Life sciences, 2019 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease with movement disorder. PD is
characterized by the loss of dopaminergic (DA) neurons in the substantia nigra. Cordycepin …

[HTML][HTML] The role of autophagy in anti-cancer and health promoting effects of cordycepin

YY Chen, CH Chen, WC Lin, CW Tung, YC Chen… - Molecules, 2021 - mdpi.com
Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been
used as an herbal complementary and alternative medicine with various biological activities …

A review on the nucleic acid constituents in mushrooms: Nucleobases, nucleosides and nucleotides

CW Phan, JK Wang, SC Cheah, M Naidu… - Critical reviews in …, 2018 - Taylor & Francis
Mushrooms have become increasingly important as a reliable food source. They have also
been recognized as an important source of bioactive compounds of high nutritional and …

Cordycepin in anticancer research: molecular mechanism of therapeutic effects

MA Khan, M Tania - Current medicinal chemistry, 2020 - ingentaconnect.com
Background: Cordycepin is a nucleotide analogue from Cordyceps mushrooms, which
occupies a notable place in traditional medicine. Objective: In this review article, we have …

Heat and light stresses affect metabolite production in the fruit body of the medicinal mushroom Cordyceps militaris

Z Jiaojiao, W Fen, L Kuanbo, L Qing, Y Ying… - Applied microbiology …, 2018 - Springer
Cordyceps militaris is a highly valued edible and medicinal fungus due to its production of
various metabolites, including adenosine, cordycepin, N 6-(2-hydroxyethyl)-adenosine, and …

Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy

N Chaicharoenaudomrung, T Jaroonwitchawan… - Toxicology in Vitro, 2018 - Elsevier
Brain cancer, in particular neuroblastoma and glioblastoma, is a global challenge to human
health. Cordycepin, extracted from Cordyceps ssp., has been revealed as a strong …

Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses

X Gong, T Li, R Wan, L Sha - International Immunopharmacology, 2021 - Elsevier
Cordycepin (CRD), an adenosine analog derived from traditional Chinese medicine, is an
active component in Cordyceps militaris. It has been shown to have many protective effects …

Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects

HS Tuli, D Kashyap, SK Bedi, P Kumar, G Kumar… - Life sciences, 2015 - Elsevier
Metal oxide nanoparticles (MO-NPs) are the multidisciplinary nano-scaled molecules which
are being used in the diagnosis and treatment of the challenging diseases including cancer …