Sex hormone signaling and regulation of immune function

JP Hoffmann, JA Liu, K Seddu, SL Klein - Immunity, 2023 - cell.com
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …

Mechanisms and consequences of sex differences in immune responses

SE Dunn, WA Perry, SL Klein - Nature Reviews Nephrology, 2024 - nature.com
Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …

The conneXion between sex and immune responses

KS Forsyth, N Jiwrajka, CD Lovell… - Nature Reviews …, 2024 - nature.com
There are notable sex-based differences in immune responses to pathogens and self-
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …

Sex-biased T-cell exhaustion drives differential immune responses in glioblastoma

J Lee, M Nicosia, ES Hong, DJ Silver, C Li, D Bayik… - Cancer discovery, 2023 - AACR
Sex differences in glioblastoma (GBM) incidence and outcome are well recognized, and
emerging evidence suggests that these extend to genetic/epigenetic and cellular …

Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications

T Xiao, J Lee, TD Gauntner, M Velegraki… - Nature Reviews …, 2024 - nature.com
Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

MEF2C regulates NK cell effector functions through control of lipid metabolism

JH Li, A Zhou, CD Lee, SN Shah, JH Ji… - Nature …, 2024 - nature.com
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare
mutations in a small subset of transcription factors can result in decreased NK cell numbers …

Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure

M Armani-Tourret, B Bone, TS Tan, W Sun… - Nature Reviews …, 2024 - nature.com
Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

Sex as a biological variable: Mechanistic insights and clinical relevance in solid organ transplantation

Y Xiao, A Schroeter, F Martin, T Matsunaga… - American Journal of …, 2023 - Elsevier
Biological sex affects immunity broadly with recognized effects on incidence and severity of
autoimmune diseases, infections and malignancies. Consequences of sex on alloimmunity …

Sex bias in immune response: it is time to include the sex variable in studies of autoimmune rheumatic diseases

LI Sakkas, IC Chikanza - Rheumatology International, 2024 - Springer
Healthy females and males differ in their immune cell composition and function and females
generally mount stronger immune response than males and are much more susceptible to …

A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults

A Ontawong, S Pengnet, A Thim-Uam, N Munkong… - Scientific Reports, 2024 - nature.com
Abstract Cordyceps militaris (L.) Link (C. militaris) contains various beneficial substances,
including polysaccharides (galactomannan), nucleotides (adenosine and cordycepin) …