Evolutionary and structural insights about potential SARS-CoV-2 evasion of nirmatrelvir
The US FDA approval of PAXLOVID, a combination therapy of nirmatrelvir and ritonavir has
significantly boosted our morale in fighting the COVID-19 pandemic. Nirmatrelvir is an …
significantly boosted our morale in fighting the COVID-19 pandemic. Nirmatrelvir is an …
[HTML][HTML] Advances in developing ACE2 derivatives against SARS-CoV-2
H Zhang, P Lv, J Jiang, Y Liu, R Yan, S Shu… - The Lancet …, 2023 - thelancet.com
Extensive immune evasion of SARS-CoV-2 rendered therapeutic antibodies ineffective in
the COVID-19 pandemic. Propagating SARS-CoV-2 variants are characterised by immune …
the COVID-19 pandemic. Propagating SARS-CoV-2 variants are characterised by immune …
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the
circulation; however, it is currently unknown whether it elicits effective immune responses in …
circulation; however, it is currently unknown whether it elicits effective immune responses in …
[HTML][HTML] Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …
individuals,–. Despite the reduced protection from infection, individuals who received three …
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2),
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
[HTML][HTML] XBB. 1.5 spike protein COVID-19 vaccine induces broadly neutralizing and cellular immune responses against EG. 5.1 and emerging XBB variants
N Patel, JF Trost, M Guebre-Xabier, H Zhou… - Scientific Reports, 2023 - nature.com
Abstract Monovalent SARS-CoV-2 Prototype (Wuhan-Hu-1) and bivalent (Prototype+ BA.
4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity …
4/5) COVID-19 vaccines have demonstrated a waning of vaccine-mediated immunity …
[HTML][HTML] A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
[HTML][HTML] A review of SARS-CoV-2 disease (COVID-19): pandemic in our time
N Al-Awwal, F Dweik, S Mahdi, M El-Dweik… - Pathogens, 2022 - mdpi.com
Development and deployment of biosensors for the rapid detection of the 2019 novel severe
acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are of utmost importance and …
acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are of utmost importance and …
Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
MA Díaz-Salinas, Q Li, M Ejemel, L Yurkovetskiy… - Elife, 2022 - elifesciences.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through
binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the …
binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the …
Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein
Worldwide SARS-CoV-2 sequencing efforts track emerging mutations in its spike protein, as
well as characteristic mutations in other viral proteins. Besides their epidemiological …
well as characteristic mutations in other viral proteins. Besides their epidemiological …