A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm,
which is characterized by a significant bulge on the vessel surface that may have …

Ascending thoracic aortic aneurysms may be fatal upon rupture or dissection and remain a
leading cause of death in the developed world. Understanding the pathophysiology of the …

Background A bicuspid aortic valve (BAV) is the most common congenital cardiac
malformation. The development of the aortic valve is closely related to the development of …

Background Type A aortic dissections (TAAD) are devastating aortic complications. Patients
with Marfan syndrome, a bicuspid aortic valve or a thoracic aortic aneurysm have an …

Background Patients with a bicuspid aortic valve (BAV) have an increased risk to develop
aortic complications. Many studies are pointing towards a possible embryonic explanation …

Background Thoracic aortopathy is a serious complication which is more often seen in
patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) than in …

During the Renaissance, Leonardo Da Vinci was the first person to successfully detail the
anatomy of the aortic root and its adjacent structures. Ever since, novel insights into …

Objective Patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve
(BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions …

Patients with a bicuspid aortic valve have an extreme high risk to develop a thoracic aortic
aneurysm and dissection (TAAD). TAADs form a leading cause of death worldwide, with the …

Introduction Bicuspid aortic valve (BAV) patients have an increased risk to develop thoracic
aortic complications. Little is known about the prevalence and severity of atherosclerosis in …