Hypertension related to obesity: pathogenesis, characteristics and factors for control
The World Health Organization (WHO) refers to obesity as abnormal or excessive fat
accumulation that presents a health risk. Obesity was first designated as a disease in 2012 …
accumulation that presents a health risk. Obesity was first designated as a disease in 2012 …
The complex role of MEG3: An emerging long non-coding RNA in breast cancer
MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse
biological processes, particularly breast cancer (BC) development. Within the imprinting …
biological processes, particularly breast cancer (BC) development. Within the imprinting …
Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
Tobacco, alcohol, and marijuana consumption is an important public health problem
because of their high use worldwide and their association with the risk of mortality and many …
because of their high use worldwide and their association with the risk of mortality and many …
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine
MJ Correia, AB Pimpão, DGF Fernandes, J Morello… - Molecules, 2022 - mdpi.com
In this review encouraged by original data, we first provided in vivo evidence that the kidney,
comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the …
comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the …
Advances in epigenetic modifications of autophagic process in pulmonary hypertension
M Mao, S Song, X Li, J Lu, J Li, W Zhao, H Liu… - Frontiers in …, 2023 - frontiersin.org
Pulmonary hypertension is characterized by pulmonary arterial remodeling that results in
increased pulmonary vascular resistance, right ventricular failure, and premature death. It is …
increased pulmonary vascular resistance, right ventricular failure, and premature death. It is …
Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation
M Rooney, T Bottiglieri, B Wasek-Patterson… - Biochimie, 2020 - Elsevier
Homozygosity for the C677T polymorphism in MTHFR (TT genotype) is associated with a 24–
87% increased risk of hypertension. Blood pressure (BP) lowering was previously reported …
87% increased risk of hypertension. Blood pressure (BP) lowering was previously reported …
Large-scale multi-omics studies provide new insights into blood pressure regulation
Recent genome-wide association studies uncovered part of blood pressure's heritability.
However, there is still a vast gap between genetics and biology that needs to be bridged …
However, there is still a vast gap between genetics and biology that needs to be bridged …
Integration of epigenetic regulatory mechanisms in heart failure
M Sopic, EL Robinson, C Emanueli… - Basic Research in …, 2023 - Springer
The number of “omics” approaches is continuously growing. Among others, epigenetics has
appeared as an attractive area of investigation by the cardiovascular research community …
appeared as an attractive area of investigation by the cardiovascular research community …
The association between Alu hypomethylation and the severity of hypertension
J Thongsroy, A Mutirangura - Plos one, 2022 - journals.plos.org
Introduction Epigenetic changes that cause genomic instability may be the basis of
pathogenic processes of age-associated noncommunicable diseases (NCDs). Essential …
pathogenic processes of age-associated noncommunicable diseases (NCDs). Essential …
DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations
The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data
and is thereby vulnerable to bias. There has been an interest in developing epigenetic …
and is thereby vulnerable to bias. There has been an interest in developing epigenetic …