Impact of stress on male fertility: role of gonadotropin inhibitory hormone

AF Odetayo, RE Akhigbe, GE Bassey… - Frontiers in …, 2024 - frontiersin.org
Studies have implicated oxidative stress-sensitive signaling in the pathogenesis of stress-
induced male infertility. However, apart from oxidative stress, gonadotropin inhibitory …

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

EE Besong, TM Akhigbe, PJ Ashonibare… - Redox …, 2023 - Taylor & Francis
Aim: The present study evaluated the effect of lead exposure with and without zinc therapy
on male sexual and erectile function. Methods: Twenty male Wistar rats were randomly …

Molecular mechanisms underpinning the protection against antiretroviral drug-induced sperm-endocrine aberrations and testicular toxicity: A review

RE Akhigbe, TM Akhigbe, PA Oyedokun… - Reproductive …, 2024 - Elsevier
The introduction of highly active antiretroviral therapy (HAART) has revolutionized the
treatment of HIV/AIDS worldwide. The HAART approach is the combination of two or more …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …

In vivo exposure to bisphenol F induces oxidative testicular toxicity: role of Erβ and p53/Bcl-2 signaling pathway

AF Odetayo, WJ Adeyemi, LA Olayaki - Frontiers in Reproductive …, 2023 - frontiersin.org
Introduction Bisphenol F (BPF), an alternative to bisphenol A has been implicated as a
gonadotoxic substance. BPF has been shown to induce hormonal imbalance and testicular …

Zinc protects against lead-induced testicular damage via modulation of steroidogenic and xanthine oxidase/uric acid/caspase 3-mediated apoptotic signaling in male …

EE Besong, PJ Ashonibare, OO Obembe… - The Aging …, 2023 - Taylor & Francis
Aim This study evaluated the effect of lead, with or without zinc co-administration, on
steroidogenic and xanthine oxidase (XO)/uric acid (UA)/caspase 3-mediated apoptotic …

Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling

AF Odetayo, WJ Adeyemi, LA Olayaki - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction Bisphenol F (BPF) has been shown to disrupt testicular functions via
perturbation of testicular redox balance, while omega-3 fatty acid (O3FA) has been …

Omega 3 fatty acid improves sexual and erectile function in BPF-treated rats by upregulating NO/cGMP signaling and steroidogenic enzymes activities

AF Odetayo, LA Olayaki - Scientific Reports, 2023 - nature.com
Bisphenol F (BPF) is an environmental pollutant that has been implicated in sexual
dysfunction. Omega 3 fatty acid (O3FA), on the other hand, is an antioxidant with the ability …

Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar …

EE Besong, PJ Ashonibare, TM Akhigbe… - Naunyn-Schmiedeberg's …, 2024 - Springer
Oxidative stress has been linked with lead toxicity, including lead-induced sexual
dysfunction. On the contrary, sodium acetate has been proven to exert antioxidant activity …

Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway

AJ Ajibare, AF Odetayo, OO Akintoye, LA Olayaki - Redox Report, 2024 - Taylor & Francis
Background: Acrylamide is a toxic substance formed in some foods that require high-
temperature cooking processes and has been implicated as a gonadotoxic agent. Zinc, on …