Structure of the Ebola virus polymerase complex

B Yuan, Q Peng, J Cheng, M Wang, J Zhong, J Qi… - Nature, 2022 - nature.com
Filoviruses, including Ebola virus, pose an increasing threat to the public health. Although
two therapeutic monoclonal antibodies have been approved to treat the Ebola virus …

Species-specific immunogenicity and protective efficacy of a vesicular stomatitis virus-based Sudan virus vaccine: a challenge study in macaques

A Marzi, P Fletcher, F Feldmann, G Saturday… - The Lancet …, 2023 - thelancet.com
Summary Background The recent Sudan virus (SUDV) outbreak in Uganda highlights the
need for rapid response capabilities, including development of vaccines against emerging …

Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques

L Santus, M Sopena-Rios, R García-Pérez… - Nature …, 2023 - nature.com
Long non-coding RNAs (lncRNAs) are involved in numerous biological processes and are
pivotal mediators of the immune response, yet little is known about their properties at the …

[HTML][HTML] Acute infection of viral pathogens and their innate immune escape

KR Rai, P Shrestha, B Yang, Y Chen, S Liu… - Frontiers in …, 2021 - frontiersin.org
Viral infections can cause rampant disease in human beings, ranging from mild to acute, that
can often be fatal unless resolved. An acute viral infection is characterized by sudden or …

Natural products as potential lead compounds to develop new antiviral drugs over the past decade

JH Zhao, YW Wang, J Yang, ZJ Tong, JZ Wu… - European Journal of …, 2023 - Elsevier
Virus infection has been one of the main causes of human death since the ancient times.
Even though more and more antiviral drugs have been approved in clinic, long-term use can …

A review on the development of gold and silver nanoparticles-based biosensor as a detection strategy of emerging and pathogenic RNA virus

N Ibrahim, ND Jamaluddin, LL Tan, NY Mohd Yusof - Sensors, 2021 - mdpi.com
The emergence of highly pathogenic and deadly human coronaviruses, namely SARS-CoV
and MERS-CoV within the past two decades and currently SARS-CoV-2, have resulted in …

[HTML][HTML] Ebola virus outbreak returns to the Democratic Republic of Congo: an urgent rising concern

J Sun, O Uwishema, H Kassem, M Abbass… - Annals of medicine and …, 2022 - Elsevier
Abstract On April 23, 2022, the Ministry of Health of the Democratic Republic of the Congo
announced an EVD outbreak after discovering 2 confirmed cases and identifying 267 …

Why doesn't Ebola virus cause pandemics like SARS-CoV-2?

M Popovic - Microbial risk analysis, 2022 - Elsevier
Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral
diseases. However, Ebola virus has never extensively spread in human population and …

Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors

J Liu, JC Trefry, AM Babka, CW Schellhase… - Science translational …, 2022 - science.org
Effective therapeutics have been developed against acute Ebola virus disease (EVD) in both
humans and experimentally infected nonhuman primates. However, the risk of viral …

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

V Monteil, H Kwon, L John, C Salata, G Jonsson… - Nature …, 2023 - nature.com
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several
outbreaks have occurred in the last decades. Although several receptors and co-receptors …