Fibroblastic reticular cells (FRCs) and their specialized collagen fibers termed 'conduits' form
fundamental structural units supporting lymphoid tissues. In lymph nodes, conduits are …

Ag retention within lymph nodes (LNs) upon vaccination is critical for the development of
adaptive immune responses, because it facilitates the encounter of the Ag with cognate …

The overpowering effect of trauma on the immune system is undisputed. Severe trauma is
characterized by systemic cytokine generation, activation and dysregulation of systemic …

The conduit network is a hallmark of lymph node microanatomy, but lack of suitable imaging
technology has prevented comprehensive investigation of its topology. We employed an …

MF59 is an oil-in-water emulsion adjuvant approved for human influenza vaccination in
European Union. The mode of action of MF59 is not fully elucidated yet, but results from …

The simulation of immune response is a challenging task because quantitative data are
scarce. Quantitative theoretical models either focus on specific cell–cell interactions or have …

Adaptive immune responses, characterized by T cells and B cells engaging and responding
to specific antigens, can be raised by biomaterials containing proteins, peptides, and other …

Neutrophils are amongst the first cells to respond to inflammation and infection. Although
they play a key role in limiting the dissemination of pathogens, the study of their dynamic …

This study aimed to establish mechanistic links between the aging-associated changes in
the functional status of mast cells and the altered responses of mesenteric tissue and …

Diverse B cell responses are important for generating antibody‐mediated protection against
highly variable pathogens. While some antigens can trigger T‐independent B cell …