[HTML][HTML] Deep learning methods for drug response prediction in cancer: predominant and emerging trends

A Partin, TS Brettin, Y Zhu, O Narykov, A Clyde… - Frontiers in …, 2023 - frontiersin.org
Cancer claims millions of lives yearly worldwide. While many therapies have been made
available in recent years, by in large cancer remains unsolved. Exploiting computational …

Artificial intelligence and machine learning in precision medicine: A paradigm shift in big data analysis

M Sahu, R Gupta, RK Ambasta, P Kumar - Progress in molecular biology …, 2022 - Elsevier
The integration of artificial intelligence in precision medicine has revolutionized healthcare
delivery. Precision medicine identifies the phenotype of particular patients with less-common …

Recent advancements, limitations, and future perspectives of the use of personalized medicine in treatment of colon cancer

A Dey, A Mitra, S Pathak, S Prasad… - … in Cancer Research …, 2023 - journals.sagepub.com
Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are
ineffective in all cases. The genomic profile and biomarkers associated with the process are …

[HTML][HTML] The development of an automated machine learning pipeline for the detection of Alzheimer's Disease

N Chedid, J Tabbal, A Kabbara, S Allouch… - Scientific Reports, 2022 - nature.com
Although Alzheimer's disease is the most prevalent form of dementia, there are no
treatments capable of slowing disease progression. A lack of reliable disease endpoints …

[HTML][HTML] Recent advances in fluorescence recovery after photobleaching for decoupling transport and kinetics of biomacromolecules in cellular physiology

N Cai, ACK Lai, K Liao, PR Corridon, DJ Graves… - Polymers, 2022 - mdpi.com
Among the new molecular tools available to scientists and engineers, some of the most
useful include fluorescently tagged biomolecules. Tools, such as green fluorescence protein …

[HTML][HTML] Future directions in regulatory affairs

O Chisholm, H Critchley - Frontiers in Medicine, 2023 - frontiersin.org
The field of regulatory affairs deals with the regulatory requirements for marketing
authorization of therapeutic products. This field is facing a myriad of forces impacting all …

Peptides as “better biomarkers”? Value, challenges, and potential solutions to facilitate implementation

A Latosinska, M Frantzi, J Siwy - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Peptides carry important functions in normal physiological and pathophysiological
processes and can serve as clinically useful biomarkers. Given the ability to diffuse …

[HTML][HTML] Development of antiepileptic drugs throughout history: from serendipity to artificial intelligence

MG Corrales-Hernández, SK Villarroel-Hagemann… - Biomedicines, 2023 - mdpi.com
This article provides a comprehensive narrative review of the history of antiepileptic drugs
(AEDs) and their development over time. Firstly, it explores the significant role of serendipity …

Dual role of PRDX1 in redox-regulation and tumorigenesis: Past and future

X Guan, Y Ruan, X Che, W Feng - Free Radical Biology and Medicine, 2023 - Elsevier
Tumour cells often display an active metabolic profile, leading to the intracellular
accumulation of reactive oxygen species. As a member of the peroxidase family …

Precision medicine with multi-omics strategies, deep phenotyping, and predictive analysis

Z Ahmed - Progress in molecular biology and translational …, 2022 - Elsevier
Precision medicine is driven by the paradigm shift of empowering clinicians to predict the
most appropriate course of action for patients with complex diseases and to improve routine …