Rationale: The incidence and sites of mucus accumulation and molecular regulation of
mucin gene expression in coronavirus (COVID-19) lung disease have not been reported …

Early-life respiratory viral infection is a risk factor for asthma development. Rhinovirus (RV)
infection of 6-d-old mice, but not mature mice, causes mucous metaplasia and airway …

Epithelial cells that line the conducting airways provide the initial barrier and innate immune
responses to the abundant particles, microbes, and allergens that are inhaled throughout …

Despite recent advances in using biologicals that target Th2 pathways, glucocorticoids form
the mainstay of asthma treatment. Asthma morbidity and mortality remain high due to the …

Besides providing an essential protective barrier, airway epithelial cells directly sense
pathogens and respond defensively. This is a frontline component of the innate immune …

Airway mucus hypersecretion is one of the most important characteristics of chronic airway
inflammatory diseases. Evaluating and managing airway mucus hypersecretion is of great …

Rationale: Goblet cell metaplasia accompanies common pulmonary disorders that are prone
to recurrent viral infections. Mechanisms regulating both goblet cell metaplasia and …

A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry
that is formed by a group of core transcription factors (TFs). These core TFs collectively …

Pneumonia is initiated by microbes in the lung, but physiological processes integrating
responses across diverse cell types and organ systems dictate the outcome of respiratory …

SAM pointed domain containing E26 transformation-specific transcription factor (SPDEF)
plays dual roles in the initiation and development of human malignancies. However, the …