Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone,
has beneficial effects on several body systems other than the musculoskeletal system. Both …

The vitamin D metabolite 1α, 25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the
transcription factor vitamin D receptor (VDR). In many tissues and cell types, VDR binds in a …

Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …

Nutrigenomics studies how environmental factors, such as food intake and lifestyle,
influence the expression of the genome. Vitamin D3 represents a master example of …

The tryptophan and kynurenine pathway is well-known to play an important role in nervous,
endocrine, and immune systems, as well as in the development of inflammatory diseases. It …

Vitamin D, a crucial hormone in the homeostasis and metabolism of calcium bone, has lately
been found to produce effects on other physiological and pathological processes …

Nutrigenomics attempts to characterize and integrate the relation between dietary molecules
and gene expression on a genome-wide level. One of the biologically active nutritional …

Vitamin D deficiency has been clearly linked to major chronic diseases associated with
oxidative stress, inflammation, and aging, including cardiovascular and neurodegenerative …

Neurodegenerative diseases, featured by progressive loss of structure or function of
neurons, are considered incurable at present. Movement disorders like tremor and postural …

The vitamin D3 metabolite 1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) activates at sub-
nanomolar concentrations the transcription factor vitamin D receptor (VDR). VDR is primarily …