Structural and functional comparison of magnesium transporters throughout evolution

GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

General aspects of metal ions as signaling agents in health and disease

K Krzywoszyńska, D Witkowska, J Świątek-Kozłowska… - Biomolecules, 2020 - mdpi.com
This review focuses on the current knowledge on the involvement of metal ions in signaling
processes within the cell, in both physiological and pathological conditions. The first section …

Ratiometric fluorescent sensors illuminate cellular magnesium imbalance in a model of acetaminophen-induced liver injury

M Brady, VI Shchepetkina… - Journal of the …, 2023 - ACS Publications
Magnesium (II) plays catalytic, structural, regulatory, and signaling roles in living organisms.
Abnormal levels of this metal have been associated with numerous pathologies, including …

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

A Kollewe, V Chubanov, FT Tseung, L Correia… - Elife, 2021 - elifesciences.org
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …

Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter

Y Huang, F Jin, Y Funato, Z Xu, W Zhu, J Wang… - Science …, 2021 - science.org
The CNNM/CorC family proteins are Mg2+ transporters that are widely distributed in all
domains of life. In bacteria, CorC has been implicated in the survival of pathogenic …

Crystal structure of an archaeal CorB magnesium transporter

YS Chen, G Kozlov, BE Moeller, A Rohaim… - Nature …, 2021 - nature.com
CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …

Two magnesium transporters in the chloroplast inner envelope essential for thylakoid biogenesis in Arabidopsis

B Zhang, C Zhang, R Tang, X Zheng, F Zhao… - New …, 2022 - Wiley Online Library
Summary Magnesium (Mg2+) serves as a cofactor for a number of photosynthetic enzymes
in the chloroplast, and is the central atom of the Chl molecule. However, little is known about …

[HTML][HTML] Recent advances in the structural biology of Mg2+ channels and transporters

F Jin, Y Huang, M Hattori - Journal of Molecular Biology, 2022 - Elsevier
Abstract Magnesium ions (Mg 2+) are the most abundant divalent cations in living organisms
and are essential for various physiological processes, including ATP utilization and the …

PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics

S Hardy, Y Zolotarov, J Coleman… - Proceedings of the …, 2023 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2,
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …

Evidence that OLE RNA is a component of a major stress‐responsive ribonucleoprotein particle in extremophilic bacteria

RR Breaker, KA Harris, SE Lyon… - Molecular …, 2023 - Wiley Online Library
OLE RNA is a~ 600‐nucleotide noncoding RNA present in many Gram‐positive bacteria that
thrive mostly in extreme environments, including elevated temperature, salt, and pH …