Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Sickle cell disease (SCD) is a monogenic blood disease caused by a point mutation in the
gene coding for β-globin. The abnormal hemoglobin [sickle hemoglobin (HbS)] polymerizes …

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a
congenital blood disorder characterized by considerable phenotypic diversity. It comprises a …

Though rare, stroke in infants and children is an important cause of mortality and chronic
morbidity in the pediatric population. Neuroimaging advances and implementation of …

Several studies implicate dysregulation of the ADAMTS-13/VWF axis as playing a major role
in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which …

In recent years, a growing number of clinical trials have been initiated to evaluate gene
therapy approaches for the treatment of patients with transfusion-dependent β-thalassemia …

A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …

The results of Voxelotor treatment in Sickle Cell Disease, as assessed through clinical
outcomes, demonstrated its efficacy in reducing hemolysis and improving hemoglobin …

Importance Despite hydroxyurea being an established treatment for sickle cell disease
(SCD), it remains underused. The recent approval of the disease-modifying treatments …

Sickle cell disease (SCD) is a life‐threatening disease requiring reliable early diagnosis. We
assessed the acceptability and diagnostic performances of two rapid diagnostic tests (RDTs) …