Single-cell genomics meets human genetics
Single-cell genomic technologies are revealing the cellular composition, identities and
states in tissues at unprecedented resolution. They have now scaled to the point that it is …
states in tissues at unprecedented resolution. They have now scaled to the point that it is …
[HTML][HTML] A compendium of genetic regulatory effects across pig tissues
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …
established to develop a public resource of genetic regulatory variants in livestock, which is …
Increasing diversity of functional genetics studies to advance biological discovery and human health
In this perspective we discuss the current lack of genetic and environmental diversity in
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …
Transcriptomic analysis reveals associations of blood-based A-to-I editing with Parkinson's disease
Background Adenosine-to-inosine (A-to-I) editing is the most common type of RNA editing in
humans and the role of A-to-I RNA editing remains unclear in Parkinson's disease (PD) …
humans and the role of A-to-I RNA editing remains unclear in Parkinson's disease (PD) …
Scientific Advancement in Trait Measurement and Quantification
The field of trait measurement and quantification has witnessed significant scientific
advancements in recent years, driven by the growing demand for precise and …
advancements in recent years, driven by the growing demand for precise and …
[HTML][HTML] Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations
S Ghatan, J van Rooij, M van Hoek, CG Boer, JF Felix… - Genome Medicine, 2024 - Springer
Abstract Background Type 2 diabetes (T2D) is a heterogeneous and polygenic disease.
Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants …
Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants …
Genetic and molecular architecture of complex traits
Human genetics has emerged as one of the most dynamic areas of biology, with a
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …
Harnessing the power of proteomics in precision diabetes medicine
N Kurgan, J Kjærgaard Larsen, AS Deshmukh - Diabetologia, 2024 - Springer
Precision diabetes medicine (PDM) aims to reduce errors in prevention programmes,
diagnosis thresholds, prognosis prediction and treatment strategies. However, its …
diagnosis thresholds, prognosis prediction and treatment strategies. However, its …
Divergent selection for feed efficiency in pigs altered the duodenum transcriptomic response to feed intake and its DNA methylation profiles
G Devailly, K Feve, S Saci, J Sarry… - Physiological …, 2024 - journals.physiology.org
Feed efficiency is a trait of interest in pigs as it contributes to lowering the ecological and
economical costs of pig production. A divergent genetic selection experiment from a Large …
economical costs of pig production. A divergent genetic selection experiment from a Large …
[HTML][HTML] From GWASs toward Mechanistic Understanding with Case Studies in Dermatogenetics
S Shen, MK Sobczyk, L Paternoster… - Journal of Investigative …, 2024 - Elsevier
Many human skin diseases result from the complex interplay of genetic and environmental
mechanisms that are largely unknown. GWASs have yielded insight into the genetic aspect …
mechanisms that are largely unknown. GWASs have yielded insight into the genetic aspect …