The regulation of fear memories is critical for adaptive behaviors and dysregulation of these
processes is implicated in trauma-and stress-related disorders. Treatments for these …

The reuniens (Re) nucleus is located in the ventral midline thalamus. It has fostered
increasing interest, not only for its participation in a variety of cognitive functions (eg, spatial …

Background & Aims Cognitive dysfunction is an increasingly recognised manifestation of
metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanistic link …

Ethnopharmacological relevance Periplaneta americana (L.)(PA) has been used in
traditional Chinese medicine for thousands of years for the effect of invigorating blood …

Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the
underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting …

Highlights•The two major diencephalic inputs to the hippocampus are the nucleus reuniens
and the supramammillary nucleus.•The nucleus reuniens serves a critical role in spatial …

The nucleus reuniens (RE) of the ventral midline thalamus is a critical node in the
communication between the orbitomedial prefrontal cortex (OFC) and the hippocampus …

A fundamental question in neuroscience is how memory formation shapes brain activity at
the level of populations of neurons. Recent studies of hippocampal engram cells, identified …

The ability to extinguish contextual fear in a changing environment is crucial for animal
survival. The'classic'neuronal circuit of contextual fear extinction includes the medial …

Aversive experiences lead to the formation of long-lasting memories. Despite the need to
better understand how enduring fear memories can be attenuated, the underlying brain …