The photorespiratory repair pathway (photorespiration in short) was set up from ancient
metabolic modules about three billion years ago in cyanobacteria, the later ancestors of …

Glutamine (Gln) is the first amino acid synthesized in nitrogen (N) assimilation in plants. Gln
synthetase (GS), converting glutamate (Glu) and NH4+ into Gln at the expense of ATP, is …

Steroids are an important family of bioactive compounds. Steroid drugs are renowned for
their multifaceted pharmacological activities and are the second-largest category in the …

The mitochondrial matrix peptidase CLPP is crucial during cell stress. Its loss causes
Perrault syndrome type 3 (PRLTS3) with infertility, neurodegeneration, and a growth deficit …

Cultured cancer cells frequently rely on the consumption of glutamine and its subsequent
hydrolysis by glutaminase (GLS). However, this metabolic addiction can be lost in the …

The identification of factors that regulate C/N utilization in plants can make a substantial
contribution to optimization of plant health. Here, we explored the contribution of pyridox …

Pyridoxal 5'-phosphate or PLP is a cofactor derived from B6 vitamers and essential for
growth in all known organisms. PLP synthesis and salvage pathways are well characterized …

Nicotinamide adenine dinucleotide (NAD+) is a common cofactor in enzyme-catalyzed
reactions that involve hydride transfers. In contrast, urocanase and urocanase-like enzymes …

Pyridoxal phosphate-dependent enzymes able to use oxygen as a co-substrate have
emerged in multiple protein families. Here, we use crystallography to solve the 2.40 Å …

Abstract Carbon‑carbon (C—C) bonds serve as the fundamental structural backbone of
organic molecules. As a critical Csingle bondC bond forming enzyme, α-oxoamine synthase …