Abstract Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For
this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase …

ΔFosB (a truncated form of FosB) and CREB (cAMP response element binding protein) are
transcription factors induced in the brain's reward pathways after chronic exposure to drugs …

Estrogens induce cell proliferation in target tissues by stimulating progression through the
G1 phase of the cell cycle. Induction of cyclin D1 expression is a critical feature of the …

The nuclear factor of activated T cells (NFAT) transcription factor is implicated in expression
of the cytokine interleukin-2 (IL-2). Binding sites for NFAT are located in the IL-2 promoter …

Breast cancer progression is likely a multistep process involving the activation and
inactivation of a number of genes. Previously, we showed that the mRNA coding for Fra-1, a …

We have previously demonstrated decreased Jun/AP-1 activity in the breast cancer cell line
MCF-7 when compared to normal or immortalized mammary epithelial cells. In this paper …

Mixed lineage kinases (MLKs) are a family of serine/threonine kinases that function in the
SAPK signaling cascade. MLKs activate JNK/SAPK in vivo by directly phosphorylating and …

The cyclin D1 gene is overexpressed in breast tumors and encodes a regulatory subunit of
cyclin-dependent kinases that phosphorylate the retinoblastoma protein. pp60 c-src activity …

The calcium-binding protein calbindin-D28k is critical for hippocampal function and
cognition,,, but its expression is markedly decreased in various neurological disorders …

The cell cycle inhibitor protein p21 WAF1/Cip1 (p21) is a critical downstream effector in p53-
dependent mechanisms of growth control and p53-independent pathways of terminal …