Since its emergence at the end of 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …

Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding,
and membrane fusion during virus entry and constitute the primary target for vaccine and …

Background Immunocompromised patients are at high risk of severe coronavirus disease
2019 (COVID-19) and death, yet treatment strategies for immunocompromised patients …

Cows produce antibodies with a disulfide-bonded antigen-binding domain embedded within
ultralong heavy chain third complementarity determining regions. This “knob” domain is …

The mutation rate of the Omicron sublineage has led to baseline resistance against all
previously authorized anti-Spike monoclonal antibodies (mAbs). Nevertheless, in case more …

Individuals with hematologic malignancies are at increased risk for severe coronavirus
disease 2019 (COVID-19), yet profound analyses of COVID-19 vaccine-induced immunity …

Abstract Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple
therapeutics targeting the virus. Development of host-directed antivirals offers broad …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe
consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in …

Rift Valley fever virus (RVFV) is an emerging mosquito-transmitted virus that circulates in
livestock and humans in Africa and the Middle East. Outbreaks lead to high rates of …