Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

Simple Summary Kidney cancer is a frequent malignant tumor that accounts for
approximately 5% of all cancer incidences. It affects both males and females, but males are …

Rationale & Objective Patients with chronic kidney disease (CKD) may be at increased risk
for cancer. CKD may also be associated with worse cancer outcomes. This study examined …

The association between chronic kidney disease (CKD) and renal cell carcinoma (RCC) is
bidirectional and multifactorial. Risk factors such as hypertension, diabetes mellitus, obesity …

Background Chronic kidney disease (CKD) is inherently a complex immune-inflammatory
condition, and heightened inflammation and immune dysfunction are closely related to an …

Background Late diagnosis is a hurdle for treatment of AKI, but targeting AKI-CKD transition
may improve outcomes. High mobility group box-1 (HMGB1) is a nuclear regulator of …

Obesity, defined by body mass index (BMI), is an established risk factor for specific renal cell
carcinoma (RCC) subtypes such as clear cell RCC, the most common RCC histology. Many …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of
transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA …

The endoplasmic reticulum is an organelle exerting crucial functions in protein production,
metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells …