Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies

K Sumaiya, D Langford, K Natarajaseenivasan… - Pharmacology & …, 2022 - Elsevier
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

MicroRNA dysregulation in gastric cancer: a new player enters the game

WKK Wu, CW Lee, CH Cho, D Fan, K Wu, J Yu… - Oncogene, 2010 - nature.com
Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of
protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have …

MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor

J Tie, Y Pan, L Zhao, K Wu, J Liu, S Sun, X Guo… - PLoS …, 2010 - journals.plos.org
MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and
function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased …

microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells

E Bandres, N Bitarte, F Arias, J Agorreta, P Fortes… - Clinical Cancer …, 2009 - AACR
Purpose: microRNAs (miRNA) are small RNAs that function as post-transcriptional
regulators of gene expression. Recent evidence has shown that some miRNAs can act as …

Macrophage migration inhibitory factor promotes tumor growth and metastasis by inducing myeloid-derived suppressor cells in the tumor microenvironment

KD Simpson, DJ Templeton, JV Cross - The Journal of Immunology, 2012 - journals.aai.org
The macrophage migration inhibitory factor (MIF), an inflammatory cytokine, is
overexpressed in many solid tumors and is associated with poor prognosis. We previously …

Biomarkers for gastric cancer screening and early diagnosis

C Herrera-Pariente, S Montori, J Llach, A Bofill… - Biomedicines, 2021 - mdpi.com
Gastric cancer is one of the most common cancers worldwide, with a bad prognosis
associated with late-stage diagnosis, significantly decreasing the overall survival. This …

ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF

F Kong, X Deng, X Kong, Y Du, L Li, H Zhu, Y Wang… - Oncogene, 2018 - nature.com
Long non-coding RNAs (lncRNAs) are implicated to be involved in the pathogenesis of
many cancers. Herein we report on our discovery of a novel lncRNA, ZFPM2 antisense RNA …

A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer

F Zhang, K Li, X Yao, H Wang, W Li, J Wu, M Li… - …, 2019 - thelancet.com
Background Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is
one of the most common treatments for GC. However, chemoresistance limits the …

[HTML][HTML] OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases

M Thiele, SC Donnelly, RA Mitchell - Journal for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with a pleiotropic
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …

Hallmarks of cancer affected by the MIF cytokine family

R Mora Barthelmess, B Stijlemans… - Cancers, 2023 - mdpi.com
Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …