There is substantial variation between individuals in the immune response to vaccination. In
this review, we provide an overview of the plethora of studies that have investigated factors …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

Background Newborns display distinct immune responses, leaving them vulnerable to
infections and impairing immunization. Targeting newborn dendritic cells (DCs), which …

The placental transfer of maternal IgG is critical for infant protection against infectious
pathogens. However, factors that modulate the placental transfer of IgG remain largely …

Due to functionally distinct cell-mediated immunity, newborns and infants are highly
susceptible to infection with intracellular pathogens. Indeed, neonatal Ag-presenting …

Highlights•TLR7/8 and C-lectins receptors are promising targets for early life adjuvants.•T
follicular helper cells are key limiting factors of early life antibody responses.•Systems …

Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of …

A growing body of evidence from epidemiologic, clinical, and immunologic studies indicates
that vaccines can influence morbidity and mortality independent of vaccine-specific B-cell or …

Single‐cell RNA sequencing allows highly detailed profiling of cellular immune responses
from limited‐volume samples, advancing prospects of a new era of systems immunology …