Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for
about 90% of cancer deaths. Although cancer survival rate has been significantly improved …

The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Since their first description, extracellular vesicles (EVs) have been the topic of avid study in a
variety of physiologic contexts and are now thought to play an important role in cancer. The …

Activity and autonomous motion are fundamental in living and engineering systems. This
has stimulated the new field of'active matter'in recent years, which focuses on the physical …

Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR)
signalling pathway is hyperactivated or altered in many cancer types and regulates a broad …

Cancer invasion and the ability of malignant tumor cells for directed migration and
metastasis have remained a focus of research for many years. Numerous studies have …

The differentiation plasticity of epithelial cells that mediates TGF-β-induced EMT and
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …