Modeling influenza virus infection: a roadmap for influenza research
Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …
Predictive markers of immunogenicity and efficacy for human vaccines
M Van Tilbeurgh, K Lemdani, AS Beignon, C Chapon… - Vaccines, 2021 - mdpi.com
Vaccines represent one of the major advances of modern medicine. Despite the many
successes of vaccination, continuous efforts to design new vaccines are needed to fight “old” …
successes of vaccination, continuous efforts to design new vaccines are needed to fight “old” …
Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis
Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that
may be further combined with the existing therapeutic modalities to enhance their effects. To …
may be further combined with the existing therapeutic modalities to enhance their effects. To …
Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity
MA Myers, AP Smith, LC Lane, DJ Moquin, R Aogo… - Elife, 2021 - elifesciences.org
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host
immune control efficacy and how different factors influence lung injury and disease severity …
immune control efficacy and how different factors influence lung injury and disease severity …
Influenza virus infection model with density dependence supports biphasic viral decay
AP Smith, DJ Moquin, V Bernhauerova… - Frontiers in …, 2018 - frontiersin.org
Mathematical models that describe infection kinetics help elucidate the time scales,
effectiveness, and mechanisms underlying viral growth and infection resolution. For …
effectiveness, and mechanisms underlying viral growth and infection resolution. For …
serosim: An R package for simulating serological data arising from vaccination, epidemiological and antibody kinetics processes
serosim is an open-source R package designed to aid inference from serological studies, by
simulating data arising from user-specified vaccine and antibody kinetics processes using a …
simulating data arising from user-specified vaccine and antibody kinetics processes using a …
Dynamics of the humoral immune response to a prime-boost Ebola vaccine: quantification and sources of variation
The Ebola vaccine based on Ad26. ZEBOV/MVA-BN-Filo prime-boost regimens is being
evaluated in multiple clinical trials. The long-term immune response to the vaccine is …
evaluated in multiple clinical trials. The long-term immune response to the vaccine is …
Mathematical modelling of chemovirotherapy cancer treatment
SS Salim, J Malinzi, E Mureithi… - International Journal of …, 2023 - Taylor & Francis
This work investigates the synergistic effects of the combination of oncolytic virotherapy and
chemotherapy on tumour cells. A mathematical model, in the form of ordinary differential …
chemotherapy on tumour cells. A mathematical model, in the form of ordinary differential …
Rational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation
Vaccines are the most effective medical intervention due to their continual success in
preventing infections and improving mortality worldwide. Early vaccines were developed …
preventing infections and improving mortality worldwide. Early vaccines were developed …
A model for establishment, maintenance and reactivation of the immune response after vaccination against Ebola virus
Abstract The 2014–2016 Ebola outbreak in West Africa has triggered accelerated
development of several preventive vaccines against Ebola virus. Under the EBOVAC1 …
development of several preventive vaccines against Ebola virus. Under the EBOVAC1 …