Histones function both positively and negatively in the regulation of gene expression, mainly
governed by post-translational modifications on specific amino acid residues. Although …

Abstract G-quadruplex (G4) structural motifs have been linked to transcription 1, 2,
replication 3 and genome instability 4, 5 and are implicated in cancer and other diseases 6 …

The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …

Minimal sets of transcription factors can directly reprogram somatic cells into neurons.
However, epigenetic remodeling during neuronal reprogramming has not been well …

Autophagy is a cell survival process essential for the regulation of immune responses to
infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here …

Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a
distinct gene expression profile, which is often accompanied by the spatial redistribution of …

For proper development, cells must retain patterns of gene expression and repression
through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by …

We have tested the specificity and utility of more than 200 antibodies raised against 57
different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and …

Abstract Histone H3 lysine 9 (H3K9) methylation is a conserved modification that generally
represses transcription. In Caenorhabditis elegans it is enriched on silent tissue-specific …

A large proportion of functional sequence within mammalian genomes falls outside protein-
coding exons and can be transcribed into long RNAs. However, the roles in mammalian …