The Caenorhabditis elegans MES proteins are key chromatin regulators of the germline.
MES-2, MES-3, and MES-6 form the C. elegans Polycomb repressive complex 2 and …

Global histone modification patterns correlate with tumor phenotypes and prognostic factors
in multiple tumor types. Recent studies suggest that aberrant histone modifications play an …

In vertebrate cells, centromeres are specified epigenetically through the deposition of the
centromere-specific histone CENP-A. Following CENP-A deposition, additional proteins are …

Di‐or tri‐methylated H3K9 (H3K9me2/3) is an epigenetic mark of heterochromatin.
Heterochromatin protein 1 (HP1) specifically recognizes H3K9me2/3, contributing to …

We have investigated the role of the histone methyltransferase G9a in the establishment of
silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in …

HP1 proteins are major components of heterochromatin, which is generally perceived to be
an inert and transcriptionally inactive chromatin structure. Yet, HP1 binding to chromatin is …

Human centromeres appear as constrictions on mitotic chromosomes and form a platform for
kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive …

Genes specifically expressed in neurons contain members with extended long introns.
Longer genes present a problem with respect to fulfilment of gene length transcription, and …

The human placenta and its specialized cytotrophoblasts rapidly develop, have a
compressed lifespan, govern pregnancy outcomes, and program the offspring's health …

During X chromosome inactivation (XCI), in female placental mammals, gene silencing is
initiated by the Xist long non‐coding RNA. Xist accumulation at the X leads to enrichment of …