Centromeres are specified epigenetically through the deposition of the centromere-specific
histone H3 variant CENP-A. However, how additional epigenetic features are involved in …

Cell differentiation is mediated by lineage‐determining transcription factors. We show that
chromodomain helicase DNA‐binding domain 2 (Chd2), a SNF2 chromatin remodelling …

Inner nuclear membrane proteins provide a structural framework for chromatin, modulating
transcription beneath the nuclear envelope. Lamin B receptor (LBR) is a classical inner …

Members of the Polycomb group of repressors and trithorax group of activators maintain
heritable states of transcription by modifying nucleosomal histones or remodeling chromatin …

The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during
transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped …

Background The processes through which the germline maintains its continuity across
generations has long been the focus of biological research. Recent studies have suggested …

ASXL1 plays key roles in epigenetic regulation of gene expression through methylation of
histone H3K27, and disruption of ASXL1 drives myeloid malignancies, at least in part, via …

Mutations in ASXL1 are frequent in patients with myelodysplastic syndrome (MDS) and are
associated with adverse survival, yet the molecular pathogenesis of ASXL1 mutations …

Senescence is a state of stable proliferative arrest, generally accompanied by the
senescence-associated secretory phenotype, which modulates tissue homeostasis …

Covalent modifications of histones play an important role in chromatin architecture and
dynamics. In particular, histone lysine methylation is important for transcriptional control …