The pursuit of enhanced health during aging has prompted the exploration of various
strategies focused on reducing the decline associated with the aging process. A key area of …

Cellular senescence refers to the permanent and irreversible cessation of the cell cycle.
Recently, it has gained significant interest as a promising target for preventing …

Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) is an
emerging pollutant transformed from 6-PPD. However, the effect of 6-PPDQ exposure on …

Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling
correlative data have been generated to support the OS theory, a direct cause-and-effect …

Alveolar epithelial cell (AEC) senescence is considered to be a universal pathological
feature of many chronic pulmonary diseases. Our previous study found that …

In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are
original were designed and synthesized. Cytotoxicity assay indicated that most of these …

Abstract Background Neural stem cells (NSCs), especially human NSCs, undergo cellular
senescence characterized by an irreversible proliferation arrest and loss of stemness after …

Osteoporosis (OP) is a systemic skeletal disorder characterized by reduced bone mass and
structural deterioration of bone tissue, resulting in heightened vulnerability to fractures due …

Background Aging is characterized by an ongoing struggle between the buildup of damage
caused by a combination of external and internal factors. Aging has different effects on …

Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis via lipid-
mediated mitochondrial dysfunction and oxidative stress. However, the mechanisms of …