Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer
S Liang, J Hess - Cells, 2024 - mdpi.com
The neurobiology of tumors has attracted considerable interest from clinicians and scientists
and has become a multidisciplinary area of research. Neural components not only interact …
and has become a multidisciplinary area of research. Neural components not only interact …
From pain to tumor immunity: influence of peripheral sensory neurons in cancer
U Mardelle, N Bretaud, C Daher, V Feuillet - Frontiers in Immunology, 2024 - frontiersin.org
The nervous and immune systems are the primary sensory interfaces of the body, allowing it
to recognize, process, and respond to various stimuli from both the external and internal …
to recognize, process, and respond to various stimuli from both the external and internal …
Pretreatment pain predicts perineural invasion in patients with head and neck squamous cell carcinoma
NN Scheff, AL Harris, J Li, NL Horan, MW Kubik… - Supportive Care in …, 2023 - Springer
Objectives Perineural invasion (PNI) in head and neck cancer (HNC) is a distinct
pathological feature used to indicate aggressive tumor behavior and drive treatment …
pathological feature used to indicate aggressive tumor behavior and drive treatment …
[HTML][HTML] Lingual Denervation Improves the Efficacy of Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinomas by Downregulating TGFβ Signaling
Purpose: Intratumoral nerve infiltration relates to tumor progression and poor survival in oral
squamous cell carcinoma (OSCC). How neural involvement regulates antitumor immunity …
squamous cell carcinoma (OSCC). How neural involvement regulates antitumor immunity …
Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications
Z Zhang, ZG Lv, M Lu, H Li, J Zhou - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
The autonomic nerve system (ANS) innervates organs and tissues throughout the body and
maintains functional balance among various systems. Further investigations have shown …
maintains functional balance among various systems. Further investigations have shown …
Context-Dependent Regulation of Peripheral Nerve Abundance by the PI3K Pathway in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma
K Khorani, S Burkart, C Weusthof, R Han, S Liang… - Cells, 2024 - mdpi.com
Recent studies have highlighted neurons and their associated Schwann cells (SCs) as key
regulators of cancer development. However, the mode of their interaction with tumor cells or …
regulators of cancer development. However, the mode of their interaction with tumor cells or …
Neuronal CFL1 upregulation in head and neck squamous cell carcinoma enhances tumor‐nerve crosstalk and promotes tumor growth
R Liu, C Wang, Z Sun, X Shi, Z Zhang… - Molecular …, 2024 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer type, marked by a
pronounced nerve density within the tumor microenvironment and a high rate of perineural …
pronounced nerve density within the tumor microenvironment and a high rate of perineural …
[HTML][HTML] Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade
EN Baruch, P Nagarajan, FO Gleber-Netto… - Research …, 2023 - ncbi.nlm.nih.gov
While the nervous system has reciprocal interactions with both cancer and the immune
system, little is known about the potential role of tumor associated nerves (TANs) in …
system, little is known about the potential role of tumor associated nerves (TANs) in …
Time to Introduce Nerve Density in Cancer Histopathologic Assessment
H Hondermarck, CC Jiang - Clinical Cancer Research, 2023 - AACR
The density of nerves in the tumor microenvironment is increasingly reported to be
associated with worse clinical outcome in various cancers. Therefore, it is time to consider …
associated with worse clinical outcome in various cancers. Therefore, it is time to consider …
Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by IL-6 blockade
While the nervous system has reciprocal interactions with both cancer and the immune
system, little is known about the potential role of tumor associated nerves (TANs) in …
system, little is known about the potential role of tumor associated nerves (TANs) in …