Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) …
L Chen, N Yao, H Yang, S Zhang, K Zhang - Cancer Chemotherapy and …, 2024 - Springer
Purpose Entrectinib (ENT) is a potent c-ros oncogene 1 (ROS1) and neurotrophic tyrosine
receptor kinase (NTRKA/B/C) inhibitor. To determine the optimum dosage of ENT using …
receptor kinase (NTRKA/B/C) inhibitor. To determine the optimum dosage of ENT using …
Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach
G Jia, C Ren, H Wang, C Fan - BMC Pharmacology and Toxicology, 2024 - Springer
This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to
predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) …
predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) …
Using a mathematical modeling to simulate pharmacokinetics and urinary glucose excretion of luseogliflozin and explore the role of SGLT1/2 in renal glucose …
Z Wang, G Wang, J Ren - ACS omega, 2022 - ACS Publications
(1) Purpose: To develop a mathematical model combining physiologically based
pharmacokinetic and urinary glucose excretion (PBPK-UGE) to simultaneously predict …
pharmacokinetic and urinary glucose excretion (PBPK-UGE) to simultaneously predict …
Mechanistic Modeling of Empagliflozin: Predicting Pharmacokinetics, Urinary Glucose Excretion, and Investigating Compensatory Role of SGLT1 in Renal Glucose …
X Ping, G Wang, D Gao - The Journal of Clinical Pharmacology, 2024 - Wiley Online Library
The aim of this study was to use a combination of physiologically based pharmacokinetic
(PBPK) modeling and urinary glucose excretion (UGE) modeling to predict the time profiles …
(PBPK) modeling and urinary glucose excretion (UGE) modeling to predict the time profiles …
Etiological Insights of Acne in Atopic Dermatitis Patients under Upadacitinib Treatment: An Exploratory Study
G Muzy - Skin Pharmacology and Physiology, 2024 - karger.com
Etiological insights of acne in atopic dermatitis patients under upadacitinib treatment: an
exploratory study Page 1 Skin Pharmacol Physiol , DOI: 10.1159/000539207 Received: January …
exploratory study Page 1 Skin Pharmacol Physiol , DOI: 10.1159/000539207 Received: January …