m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer

BJ Petri, CM Klinge - Journal of molecular endocrinology, 2023 - jme.bioscientifica.com
Epitranscriptomic modification of RNA regulates human development, health, and disease.
The true diversity of the transcriptome in breast cancer including chemical modification of …

N6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs–an updated review

Y Zhang, Y Xu, Y Bao, Y Luo, G Qiu, M He, J Lu, J Xu… - Epigenetics, 2023 - Taylor & Francis
Osteosarcoma, originating from primitive bone-forming mesenchymal cells, is the most
common malignant bone tumour among children and adolescents. N6-methyladenosine …

The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer

Y Zhu, J Li, H Yang, X Yang, Y Zhang, X Yu, Y Li… - Cell Death …, 2023 - nature.com
Abstract m6A is an important RNA methylation in progression of various human cancers. As
the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation …

The function and clinical implication of YTHDF1 in the human system development and cancer

W Ren, Y Yuan, Y Li, L Mutti, J Peng, X Jiang - Biomarker Research, 2023 - Springer
YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation,
stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene …

m6A methylation: Critical roles in aging and neurological diseases

Y Fan, X Lv, Z Chen, Y Peng, M Zhang - Frontiers in Molecular …, 2023 - frontiersin.org
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotic
cells, which participates in the functional regulation of various biological processes. It …

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases

Y Xu, Y Zhang, Y Luo, G Qiu, J Lu, M He… - Cell Death Discovery, 2023 - nature.com
Abstract N6-methyladenosine (m6A) modification, catalyzed by methyltransferase
complexes (MTCs), plays many roles in multifaceted biological activities. As the most …

METTL3 mediated MALAT1 m6A modification promotes proliferation and metastasis in osteosarcoma cells

Y Zhang, Y Xu, G Qiu, Y Luo, Y Bao, J Lu, T Wang… - Molecular …, 2023 - Springer
Background As one of the most ubiquitous types of posttranscriptional modification, N6-
methyladenosine (m6A) is extensively implicated in almost all types of cancers, including …

Recent advances of m6A methylation in skeletal system disease

J Liang, Q Yi, Y Liu, J Li, Z Yang, W Sun… - Journal of Translational …, 2024 - Springer
Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system
with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 …

[HTML][HTML] Novel insights into the regulatory role of N6-methyladenosine methylation modified autophagy in sepsis

CF Bi, J Liu, XD Hu, LS Yang, JF Zhang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. It is characterized by high morbidity and mortality and one of the major …

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy

A Guan, JJL Wong - Cancer Medicine, 2024 - Wiley Online Library
Abstract The N6‐methyladenosine (m6A) RNA modification has gained significant
prominence as a new layer of regulatory mechanism that governs gene expression. Over the …