Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Stimulator of interferon genes (STING) contributes to immune responses against tumors and
may control viral infection including SARS-CoV-2 infection. However, activation of the STING …

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied
regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially …

Osteoporosis is a common metabolic bone disease that results from the imbalance of
homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …

Ischemic stroke (IS) accounts for more than 80% of the total stroke, which represents the
leading cause of mortality and disability worldwide. Cerebral ischemia/reperfusion injury …

Ethnopharmacological relevance Liquiritin is a flavonoid derived from Radix et Rhizoma
Glycyrrhizae, which is a widely used traditional Chinese medicine with the effects of …