The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …

Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the
functional effector or memory T cell states,,,,–. Here we identify the nuclear factor TOX as a …

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed
a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor …

Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

Tumour-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to
progress. The epigenetic regulation of T cell dysfunction and therapeutic reprogrammability …

CD8+ T cells recognizing tumor-specific antigens are detected in cancer patients but are
dysfunctional. Here we developed a tamoxifen-inducible liver cancer mouse model with a …

The facultative intracellular bacterium Listeria monocytogenes (Lmo) has great potential for
development as a cancer vaccine platform given its properties. However, the clinical …

Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …