[HTML][HTML] The bioprinting roadmap

W Sun, B Starly, AC Daly, JA Burdick, J Groll… - …, 2020 - iopscience.iop.org
This bioprinting roadmap features salient advances in selected applications of the technique
and highlights the status of current developments and challenges, as well as envisioned …

Engineering cell membrane‐based nanotherapeutics to target inflammation

H Yan, D Shao, YH Lao, M Li, H Hu… - Advanced …, 2019 - Wiley Online Library
Inflammation is ubiquitous in the body, triggering desirable immune response to defend
against dangerous signals or instigating undesirable damage to cells and tissues to cause …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …

[HTML][HTML] Breaking bottlenecks for the TCR therapy of cancer

L Gaissmaier, M Elshiaty, P Christopoulos - Cells, 2020 - mdpi.com
Immune checkpoint inhibitors have redefined the treatment of cancer, but their efficacy
depends critically on the presence of sufficient tumor-specific lymphocytes, and cellular …

Innovation and competition in advanced therapy medicinal products

E Seoane‐Vazquez, V Shukla… - EMBO molecular …, 2019 - embopress.org
Advanced therapy medicinal products (ATMPs), including gene therapy, cell therapy, and
tissue engineering products, represent a paradigm shift in health care as they have great …

Biphasic response of T cell activation to substrate stiffness

DJ Yuan, L Shi, LC Kam - Biomaterials, 2021 - Elsevier
T cell activation is sensitive to the mechanical properties of an activating substrate. However,
there are also contrasting results on how substrate stiffness affects T cell activation …

[HTML][HTML] Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ–stimulated mesenchymal stromal cells that predict …

RA Marklein, MW Klinker, KA Drake, HG Polikowsky… - Cytotherapy, 2019 - Elsevier
Background Although a preponderance of pre-clinical data demonstrates the
immunosuppressive potential of mesenchymal stromal cells (MSCs), significant …

[HTML][HTML] High throughput screening of mesenchymal stem cell lines using deep learning

G Kim, JH Jeon, K Park, SW Kim, DH Kim, S Lee - Scientific Reports, 2022 - nature.com
Mesenchymal stem cells (MSCs) are increasingly used as regenerative therapies for
patients in the preclinical and clinical phases of various diseases. However, the main …

[HTML][HTML] Leukocyte-derived biomimetic nanoparticulate drug delivery systems for cancer therapy

Y Huang, X Gao, J Chen - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Precise drug delivery to tumors with low system toxicity is one of the most important and
challenging tasks for pharmaceutical researchers. Despite progress in the field of …

[HTML][HTML] Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy

OF Garcia-Aponte, C Herwig, B Kozma - Journal of Biological Engineering, 2021 - Springer
Bioreactors are essential tools for the development of efficient and high-quality cell therapy
products. However, their application is far from full potential, holding several challenges …