[HTML][HTML] From Cytokine Storm to Cytokine Breeze: Did Lessons Learned from Immunopathogenesis Improve Immunomodulatory Treatment of Moderate-to-Severe …
G Rondovic, D Djordjevic, I Udovicic, I Stanojevic… - Biomedicines, 2022 - mdpi.com
Complex immune response to infection has been highlighted, more than ever, during the
COVID-19 pandemic. This review explores the immunomodulatory treatment of moderate-to …
COVID-19 pandemic. This review explores the immunomodulatory treatment of moderate-to …
Sustained viral suppression with dolutegravir monotherapy over 192 weeks in patients starting combination antiretroviral therapy during primary human …
Background Starting combination antiretroviral therapy (cART) during primary human
immunodeficiency virus type 1 (HIV-1) infection results in a smaller HIV-1 latent reservoir …
immunodeficiency virus type 1 (HIV-1) infection results in a smaller HIV-1 latent reservoir …
[HTML][HTML] COVID-19 patients with high TNF/IFN-γ levels show hallmarks of PANoptosis, an inflammatory cell death
Y Palacios, LA Ramón-Luing, A Ruiz… - Microbes and …, 2023 - Elsevier
TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can
induce senescence and a cell death process called PANoptosis. This study included 138 …
induce senescence and a cell death process called PANoptosis. This study included 138 …
[HTML][HTML] FDA-approved inhibitors of RTK/raf signaling potently impair multiple steps of in vitro and ex vivo influenza A virus infections
R Meineke, S Stelz, M Busch, C Werlein, M Kühnel… - Viruses, 2022 - mdpi.com
Influenza virus (IV) infections pose a burden on global public health with significant
morbidity and mortality. The limited range of currently licensed IV antiviral drugs is …
morbidity and mortality. The limited range of currently licensed IV antiviral drugs is …
[HTML][HTML] In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury
S Giannakopoulos, DP Strange, B Jiyarom… - PLoS …, 2023 - journals.plos.org
The hallmark of severe COVID-19 involves systemic cytokine storm and multi-organ injury
including testicular inflammation, reduced testosterone, and germ cell depletion. The ACE2 …
including testicular inflammation, reduced testosterone, and germ cell depletion. The ACE2 …
[HTML][HTML] Tocilizumab vs. baricitinib in hospitalized severe COVID-19 patients: results from a real-world cohort
M Karolyi, A Gruebl, S Omid, M Saak, E Pawelka… - Infection, 2023 - Springer
Background Tocilizumab and baricitinib are recommended treatment options for
hospitalized COVID-19 patients requiring oxygen support. Literature about its efficacy and …
hospitalized COVID-19 patients requiring oxygen support. Literature about its efficacy and …
[HTML][HTML] Polymeric Materials as Indispensable Tools to Fight RNA Viruses: SARS-CoV-2 and Influenza A
ACF Santos, F Martel, CSR Freire, BJML Ferreira - Bioengineering, 2022 - mdpi.com
Towards the end of 2019 in Wuhan, suspicions of a new dangerous virus circulating in the
air began to arise. It was the start of the world pandemic coronavirus disease 2019 (COVID …
air began to arise. It was the start of the world pandemic coronavirus disease 2019 (COVID …
Harnessing endogenous peptide compounds as potential therapeutics for severe influenza
AC West, CM Harpur, MA Le Page… - The Journal of …, 2023 - academic.oup.com
Background Excessive pulmonary inflammation and damage are characteristic features of
severe influenza virus infections. LAT8881 is a synthetic 16–amino acid cyclic peptide form …
severe influenza virus infections. LAT8881 is a synthetic 16–amino acid cyclic peptide form …
Clinical and prognostic value of parameters of cytokine regulation in oxygen-dependent patients with the coronavirus disease COVID-19
Aim of the work is to find out the clinical and prognostic significance of cytokine regulation
parameters in oxygen-dependent patients with COVID-19 coronavirus disease in dynamics …
parameters in oxygen-dependent patients with COVID-19 coronavirus disease in dynamics …
Inactivated sars-cov-2 reprograms the tumor immune microenvironment and improves murine cancer outcomes
Following the breakthrough of immune check point inhibitors (ICIs), a new era of immuno-
oncology agents has emerged and established immunotherapy as a part of cancer …
oncology agents has emerged and established immunotherapy as a part of cancer …