An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

The old people often suffer from circadian rhythm disturbances, which in turn accelerate
aging. Many aging-related degenerative diseases such as Alzheimer's disease, Parkinson's …

Advanced age is the largest risk factor for late‐onset Alzheimer's disease (LOAD), a disease
in which susceptibility correlates to almost all hallmarks of aging. Shared genetic signatures …

The circadian rhythm is a self-sustaining 24 h cycle that regulates physiological processes
within the body, including cycles of alertness and sleepiness. Cells have their own intrinsic …

Background and purpose The prevalence of cerebral small vessel disease (CSVD) is
increasing due to the accelerating global aging process, resulting in a substantial burden on …

Circadian rhythms,~ 24 h cycles of physiological and behavioral processes, can be
synchronized by external signals (eg, light) and persist even in their absence. Consequently …

The amount of sleep needed over one's lifespan is age dependent and not sleeping enough
or sleeping in excess is associated with increased morbidity and mortality. Yet, the …

Alzheimer's disease (AD) is the most common type of dementia, which is characterised by
progressive memory loss and accumulation of hallmark markers amyloid-β (Aβ) and …

Background Alzheimer's disease (AD) is a common neurodegenerative disorder that has a
multi-step disease progression. Differences between moderate and advanced stages of AD …