[HTML][HTML] Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's disease: a systematic review
WA Rike, S Stern - International Journal of Molecular Sciences, 2023 - mdpi.com
The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …
The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
[HTML][HTML] Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients
L Mizrahi, A Choudhary, P Ofer, G Goldberg… - Molecular …, 2023 - nature.com
Bipolar disorder (BD) is a neuropsychiatric mood disorder manifested by recurrent episodes
of mania and depression. More than half of BD patients are non-responsive to lithium, the …
of mania and depression. More than half of BD patients are non-responsive to lithium, the …
[HTML][HTML] Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations
Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …
[HTML][HTML] Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and
environmental factors are known to play a role in this psychiatric disorder. While there is a …
environmental factors are known to play a role in this psychiatric disorder. While there is a …
[HTML][HTML] Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophrenia
Background Postmortem studies in schizophrenia consistently show reduced dendritic
spines in the cerebral cortex but the mechanistic underpinnings of these deficits remain …
spines in the cerebral cortex but the mechanistic underpinnings of these deficits remain …
[HTML][HTML] Advances in the knowledge and therapeutics of schizophrenia, major depression disorder, and bipolar disorder from human brain organoid research
R Villanueva - Frontiers in Psychiatry, 2023 - frontiersin.org
Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed
to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that …
to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that …
[HTML][HTML] Upregulated ECM genes and increased synaptic activity in Parkinson's human DA neurons with PINK1/ PRKN mutations
U Tripathi, I Rosh, R Ben Ezer, R Nayak… - npj Parkinson's …, 2024 - nature.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Primary
symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra …
symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra …
Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson's disease patients with PINK1 …
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Primary
symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra …
symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra …
[HTML][HTML] iPSC-derived hippocampal neurons from discordant monozygotic twins to understand the pathophysiology of Schizophrenia
A Choudhary - Neuroscience, 2024 - communities.springernature.com
Schizophrenia (SCZ) is characterized mainly by hallucinations, delusions, and mental
confusion and occurs at the rate of approximately 1% in the general population 1. Dr. Emile …
confusion and occurs at the rate of approximately 1% in the general population 1. Dr. Emile …