Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis

K Ghoreschi, A Balato, C Enerbäck, R Sabat - The Lancet, 2021 - thelancet.com
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Alopecia areata: an update on etiopathogenesis, diagnosis, and management

C Zhou, X Li, C Wang, J Zhang - Clinical Reviews in Allergy & …, 2021 - Springer
Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in
hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has …

European guideline (EuroGuiDerm) on atopic eczema: part I–systemic therapy

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

European guideline (EuroGuiDerm) on atopic eczema–part II: non‐systemic treatments and treatment recommendations for special AE patient populations

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

Pyoderma gangrenosum: an updated literature review on established and emerging pharmacological treatments

CA Maronese, MA Pimentel, MM Li… - American Journal of …, 2022 - Springer
Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of
neutrophilic dermatoses and clinically characterized by painful, rapidly evolving cutaneous …

New treatment addressing the pathogenesis of psoriasis

M Tokuyama, T Mabuchi - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL) 23/IL17
axis plays an important role in the development of psoriasis. The effectiveness of biologic …

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement

P Nash, A Kerschbaumer, T Dörner… - Annals of the …, 2021 - ard.bmj.com
Objectives Janus kinase inhibitors (JAKi) have been approved for use in various immune-
mediated inflammatory diseases. With five agents licensed, it was timely to summarise the …

Current concepts of psoriasis immunopathogenesis

M Vičić, M Kaštelan, I Brajac, V Sotošek… - International Journal of …, 2021 - mdpi.com
Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the
skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is …

JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition

Y Luo, M Alexander, M Gadina, JJ O'Shea… - Journal of Allergy and …, 2021 - Elsevier
Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

[HTML][HTML] Phase 3 efficacy and safety of abrocitinib in adults with moderate-to-severe atopic dermatitis after switching from dupilumab (JADE EXTEND)

VY Shi, T Bhutani, L Fonacier, M Deleuran… - Journal of the American …, 2022 - Elsevier
Background Abrocitinib efficacy by prior dupilumab response status in patients with
moderate-to-severe atopic dermatitis has not previously been assessed in phase 3 studies …