Over the past 5 years, a new generation of highly potent and broadly neutralizing HIV-1
antibodies has been identified. These antibodies can protect against lentiviral infection in …

The epitopes defined by HIV-1 broadly neutralizing antibodies (bNAbs) are valuable
templates for vaccine design, and studies of the immunological development of these …

Recombinant trimeric mimics of the human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein (Env) spike should expose as many epitopes as possible for broadly …

Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist
in metastable pre-fusogenic states that may be stabilized by directed rational design. As …

Induction of HIV‐1 broadly neutralizing antibodies (bnAbs) to date has only been observed
in the setting of HIV‐1 infection, and then only years after HIV transmission. Thus, the …

The induction of neutralizing antibodies directed against the human immunodeficiency virus
(HIV) has received considerable attention in recent years, in part driven by renewed interest …

Background Presenting vaccine antigens in particulate form can improve their
immunogenicity by enhancing B cell activation. Findings We describe ferritin-based protein …

INTRODUCTION Inducing protective antibodies is a key goal in HIV-1 vaccine development.
In acute HIV-1 infection, the dominant initial plasma antibody response is to the gp41 …

Structures of BG505 SOSIP. 664 trimer in complex with broadly neutralizing antibodies
(bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1 …

The identification of a new generation of potent broadly neutralizing HIV-1 antibodies
(bnAbs) has generated substantial interest in their potential use for the prevention and/or …