Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes
The isolation of broadly neutralizing HIV-1 monoclonal antibodies (MAbs) to distinct
epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations …
epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations …
[HTML][HTML] Insights into the structural basis of antibody affinity maturation from next-generation sequencing
AK Mishra, RA Mariuzza - Frontiers in immunology, 2018 - frontiersin.org
Affinity maturation is the process whereby the immune system generates antibodies of
higher affinities during a response to antigen. It is unique in being the only evolutionary …
higher affinities during a response to antigen. It is unique in being the only evolutionary …
Insights into the trimeric HIV-1 envelope glycoprotein structure
AB Ward, IA Wilson - Trends in biochemical sciences, 2015 - cell.com
The HIV-1 envelope glycoprotein (Env) trimer is responsible for receptor recognition and
viral fusion with CD4+ T cells, and is the sole target for neutralizing antibodies. Thus …
viral fusion with CD4+ T cells, and is the sole target for neutralizing antibodies. Thus …
Broadly neutralizing antibodies targeting HIV: Progress and challenges
Anti-HIV broadly neutralizing antibodies (bNAbs) offer a novel approach to treating,
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
[HTML][HTML] Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope
Broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals inform HIV-
1 vaccine design efforts. Developing bNAbs with increased efficacy requires understanding …
1 vaccine design efforts. Developing bNAbs with increased efficacy requires understanding …
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization
Rationally designed protein subunit vaccines are being developed for a variety of viruses
including influenza, RSV, SARS-CoV-2, and HIV. These vaccines are based on stabilized …
including influenza, RSV, SARS-CoV-2, and HIV. These vaccines are based on stabilized …
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529
Abstract The HIV-1 envelope (Env) spike is a conformational machine that transitions
between prefusion (closed, CD4-and CCR5-bound) and postfusion states to facilitate HIV-1 …
between prefusion (closed, CD4-and CCR5-bound) and postfusion states to facilitate HIV-1 …
Structure and immune recognition of the HIV glycan shield
Vaccine design efforts against the human immunodeficiency virus (HIV) have been greatly
stimulated by the observation that many infected patients eventually develop highly potent …
stimulated by the observation that many infected patients eventually develop highly potent …
HIV-1 vaccine design through minimizing envelope metastability
Overcoming envelope metastability is crucial to trimer-based HIV-1 vaccine design. Here,
we present a coherent vaccine strategy by minimizing metastability. For 10 strains across …
we present a coherent vaccine strategy by minimizing metastability. For 10 strains across …
Effect of HIV-1 Env on SERINC5 antagonism
ABSTRACT SERINC5 is able to restrict HIV-1 infection by drastically impairing the infectivity
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …