Antibiotics are essential agents that have greatly reduced human mortality due to infectious
diseases. Their use, and sometimes overuse, have increased over the past several decades …

Antibiotic resistance describes a set of conditions whereby a microorganism is able to
survive exposure to an antibiotic. Whereas a genetic mutation in bacteria, whether …

Antibiotic use is widely accepted as being responsible for the selection and maintenance of
antibiotic resistance. It is less obvious, however, that it is also responsible for increasing …

Although the epidemiology of methicillin‐resistant Staphylococcus aureus (MRSA) varies
across Europe, healthcare‐associated MRSA infections are common in many countries …

Quinolones are among the most commonly prescribed antibiotics worldwide. A clear
relationship has been demonstrated between excessive quinolone use and the steady …

The discovery of penicillin undoubtedly transformed the management of life-threatening
bacterial infections. However, a less comfortable aspect of the antibiotic revolution was that …

In our tertiary university hospital, fluoroquinolones were prohibited during 2001 leading to a
90% reduction in their use. Our objective was to examine the trends in meticillin-resistant …

Objectives We evaluated the effect of implementation of an electronic medical record (EMR)
on the use of antimicrobial agents and on the rates of infections with Clostridium difficile and …

Fitness cost associated with resistance to fluoroquinolones was recently shown to vary
across clones of methicillin-resistant Staphylococcus aureus and extended-spectrum β …

Background Fluoroquinolones are frequently prescribed for non complicated urinary tract
infection treatments and have a negative ecological impact. We aimed to substitute them by …