Innovations, Opportunities, and Challenges for Predicting Alteration in Drug-Metabolizing Enzyme and Transporter Activity in Specific Populations
Drug-metabolizing enzymes and transporters (DMETs) are key regulators of the
pharmacokinetics, efficacy, and toxicity of therapeutics. Over the past two decades …
pharmacokinetics, efficacy, and toxicity of therapeutics. Over the past two decades …
The extent of cytochrome P450 3A induction by antiseizure medications: A systematic review and network meta‐analysis
H Cohen, G Mahajna, T Ben‐Shushan, I Matok… - …, 2024 - Wiley Online Library
Abstract Objective Antiseizure medications (ASMs) are commonly categorized as enzyme‐
inducers and non‐enzyme‐inducers based on their propensity to enhance the metabolism …
inducers and non‐enzyme‐inducers based on their propensity to enhance the metabolism …
Incorporation and performance verification of hepatic portal blood flow shunting in minimal and full PBPK models of liver cirrhosis
Patho‐physiological changes in liver cirrhosis create portacaval shunts that allow blood flow
to bypass the hepatic portal vein into the systemic circulation affecting drug …
to bypass the hepatic portal vein into the systemic circulation affecting drug …
[HTML][HTML] Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in …
X Luo, Z Zhang, R Mu, G Hu, L Liu, X Liu - Pharmaceutics, 2024 - mdpi.com
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients
or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically …
or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically …
Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model
Abstract Hepatic impairment (HI) moderately (< 5‐fold) affects the systemic exposure (ie,
area under the plasma concentration–time curve [AUC]) of drugs that are substrates of the …
area under the plasma concentration–time curve [AUC]) of drugs that are substrates of the …